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Armodafinil helps to improve wakefulness

Armodafinil Pharmacology.

Armodafinil is found to be the R-enantiomer of racemic modafinil and has many of its properties and features. The same as Modafinil Generic Armodafinil is the oral wake-promoting agent which is completely different from all those stimulants which are used for sustaining central nervous system. Armodafinil includes R-modafinil when racemic modafinil includes a mix of both S-modafinil and R-modafinil. It is not fully understandable how the medication works. It is supposed that it has some selective effects on the central nervous system through serotonergic, noradrenergic and dopaminergic receptors.

All above mentioned effects are not completely described. It is already known that the medication can bind to the dopamine and inhibit its reuptake. But at the same time the drug is not considered to be an agonist of dopamine receptor. It is believed that those hypocretin –producing neurons in the hypothalamus are activated by the medication which helps in releasing norepinephrine and dopamine and promoting wakefulness. Besides this, the drug can increase electrical coupling between the neurons, simultaneously potentiating a feeling of wakefulness. A dose of 200 mg is well absorbed, when is taken orally, including good, even maximum plasma medication concentration. The effects are achieved in 2 hours approximately. Such benefits of the medication are very valuable.

If you have one dose of the medication per day it will gain its steady sate after 7 days approximately. The bioavailability of the medicine is not affected by meal. When taken postprandially, the absorption rate is delayed 2-4 hours. The medication is quite well distributed outside vascular system, but at the same time its affinity concerning tissues is not high. The medication is not likely to interact with different protein-bound medicines. Furthermore, it binds to albumin in a moderate degree. The drug is metabolized by amide hydrolysis which is followed by formation of sulfone through cytochrome P450 enzyme pathway.

The adjustments of Armodafinil doses may be necessary when the patients have concomitant medicines which are metabolized through this pathway as well. The drug inhibits in a moderate way CYP2C19 activity. The drugs which are metabolized through enzyme can show prolonged elimination, which requires low doses of such agents when receiving them simultaneously with Armodafinil. The elimination of Armodafinil is really monophasic with a little elimination half life of 15 hours. It differs from half-life elimination of S-enantiomer, which is almost 3 or 4 times shorter than that of Armodafinil. The medication has a good systemic availability. It is recommended to consider lower doses of Armodafinil for elderly patients, those who suffer from severe hepatic impairment.

Armodafinil Efficacy.

Many people who faced with abnormal excessive sleep are advised to buy Armodafinil. It is a very effective and safe drug which brings the least of side effects. It is well tolerated and can be taken almost by everyone, excluding children. It is not yet known whether the medication is good or bad for them. Of course, with time there would be investigations which would find out Armodafinil efficacy in pediatric patients. In some preclinical trials, there was taken a rat model with sleep deprivation in order to find out and explore Armodafinil efficacy compared to such a stimulant, as D-methamphetamine, which is also used for promoting wakefulness in adult patients. At the end of the study it was revealed that both agents showed the same wakefulness-promoting results.

But in comparison with the stimulant methamphetamine, Generic Armodafinil didn’t induce the signs of sleep deprivation, including acute rebound hyper somnolence. The study revealed that half-life of Armodafinil is accompanied with sustained and better attention and enhanced wakefulness. Nowadays it has become very easy to order Armodafinil online without any additional problems. It is not even necessary to have a prescription from the doctor. Such an easy access to the drug explains its current popularity.

You just need to register in one of those online pharmacies, receive consultation and order the medication in that quantity you require. When the drug was given orally for those volunteers, who very healthy and didn’t suffer from sleeping disorders Armodafinil showed considerable results in enhancing wakefulness in comparison with a simple placebo.  The drug can be a very good option for those people who faced with ES due to the number of reasons.

Armodafinil is relatively new drug which has already gained much popularity among the population. It is safe and non abusive.